Synonym: (ÃÂ±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-ÃÂ±-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)
Empirical Formula (Hill Notation): C8H14O2S2
Molecular Weight: 206.33
CAS Number: 1077-28-7
|solubility||ethanol: soluble50 mg/mL|
|Gene Information|| human ... ACHE(43), BCHE(590)|
rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
1, 5, 25, 50 g in poly bottle
500 mg in poly bottle
(ÃÂ±)-ÃÂ±-Lipoic acid (ÃÂ±-LA) is soluble in ethanol at 50 mg/ml
ÃÂ±-LA can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats4. It has also been used to analyze ROS production in astrocytes5.
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-ÃÂºB. Decreases the phagocytosis of myelin by macrophages.
Features and Benefits
This compound is also offered as part of SigmaÃ¢â¬Â²s Library of Pharmacologically Active Compounds (LOPACÃÂ®1280), a biologically annotated collection of high-quality, ready-to-screen compounds.
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