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(S)-(+)-Camptothecin

(S)-(+)-Camptothecin
(S)-(+)-Camptothecin
Price And Quantity
  • 1
  • Kilograms/Kilograms
  • 100 Onwards INR
Product Specifications
  • 275 to 277 °C (527 to 531 °F)
  • 757.0±60.0 °C at 760 mmHg
  • C20H16N2O4
  • 348.352 Grams (g)
  • As a result of these efforts, two camptothecin analogs have been approved for cancer therapy: Topotecan (hycamtin) is approved for the treatment of recurring ovarian cancer, small cell lung cancer, and in combination with cisplatin for cervical cancer; irinotecan (camptosar) is prescribed for advanced cancers of the ...
  • Camptothecin
    Product Description

    (S)-(+)-Camptothecin


      • Empirical Formula (Hill Notation): C20H16N2O4

      • Molecular Weight: 348.35

      • CAS Number: 7689-03-4

        assay  


        ≥90% (HPLC)
        form   powder
        mp   260 Â°C (dec.)(lit.)
        solubility   chloroform/methanol (4:1): soluble5 mg/mL
        Mode of action   DNA synthesis | interferes
          enzyme | inhibits
        storage temp.   2-8°C
        Gene Information   human ... TOP1(7150)
        mouse ... Prkca(18750)
        rat ... Sstr2(54305)

        Description

        Other Notes

        20S isomer

        Packaging

        1 g in glass bottle

        100, 250 mg in glass bottle

        Biochem/physiol Actions

        (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

        Features and Benefits

        This compound is a featured product for Apoptosis research.

         

    Trade Information
    • Cash in Advance (CID), Cash Advance (CA)
    • 500 KG Per Month
    • 2-8 Week
    • Yes
    • Sample costs shipping and taxes has to be paid by the buyer
    • Carton and Poly Bag.
    • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia
    • All India
      Contact Us

      Kesarkunj, Room No. 9, 2 Nd Floor, Vasanji Lalji Road, Kandivali Station Road, Opp. Mcdonlad's, Near Jain Restaurant, Kandivali (West), Mumbai, Maharashtra, 400067, India
      Phone :+918037405224