AquaSolve Hypromellose Acetate Succinate (HPMCAS)

AquaSolve Hypromellose Acetate Succinate (HPMCAS)
AquaSolve Hypromellose Acetate Succinate (HPMCAS)
Price And Quantity
  • Piece/Pieces
  • 1
  • Piece/Pieces
  • 100 INR
    Product Description
    AquaSolve Hypromellose Acetate Succinate (HPMCAS) 

    AquaSolve HPMCAS is a mixture of acetic acid andmonosuccinic acid esters of hydroxypropylmethylcellulose. AquaSolve HPMCAS isused as a solid dispersion polymer for bioavailability enhancement of poorlysoluble active pharmaceutical ingredients(APIs). The versatility of thispolymer in addressing solubility issues is a result of its unique properties.These properties lead to enhanced absorption when HPMCAS-based soliddispersions are dosed orally.


    Features and benefits of AquaSolve HPMCAS



    Several substitution ranges

    Low solution viscosity in multiple organic solvents

    High Tg

    Performance matches monographcompliant competitiveproducts

    HPMCAS is amphiphilic

    Enteric polymer, so partially ionized above pH 5



    Scope for API-dependent formulation flexibility

    Economical and controllable spray-dried dispersionprocesses

    Excellent physical stability due to low drug mobility

    Reduced risk in excipient sourcing and ease ofinterchangeability

    Insoluble drug molecules interact with the hydrophobicregions; hydrophilic regions allow the formation of colloids in aqueous solution

    Charge on the polymer minimizes the formation of largeagglomerates, thus stabilizing drug-polymer colloids


    AquaSolve HPMCAS is also used as an enteric coatingpolymer and in preparation of sustained drug-release formulations; the releaserate of the API from the matrix is pH dependent.


    AquaSolve HPMCAS is available in three gradesdifferentiated by degree/ratio of substitution. Each grade is available in twoparticle sizes. Consult the product data sheet or the excipient informationpackage for further details on specifications. Additional substitution levelsand ranges are available upon request. Detailed product information isavailable in the AquaSolveâ„¢ Hydroxypropylmethylcellulose Acetate SuccinatePhysical and Chemical Properties Handbook.

    Trade Information
    • Cash Advance (CA), Cash in Advance (CID)
    • 3-4 Per Month
    • Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
    • All India
    • ISO CERTIFICATE: 9001:2015
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